Developmental and Reproductive Toxicology (DART)

About Developmental and Reproductive Toxicology (DART):

Smithers Viscient evaluates reproduction and development for assessment of potential human reproductive risk. Each study is designed to meet the specifications of the appropriate scientific and regulatory guidance. Services include Extended One Generation Reproductive Toxicity Study (EOGRTS).

Scope and Range of Developmental and Reproductive Toxicology (DART) Services:

  • The team has extensive experience conducting GLP-compliant DART studies that meet global regulatory test guidelines (ICH, FDA, EPA, OECD, EU, and MHLW)
  • Highly experienced management
  • Established leading animal welfare program
  • Strong track record of regulatory complianceWell-documented history of on-time reporting
  • Studies for preclinical development of large and small molecules
  • Routine and specialized routes of dose administration
  • Fertility (male and/or female)
  • Embryo-fetal development
  • Prenatal and postnatal development, including maternal function
  • Maternal antibody transfer
  • Postnatal development assessment
    • Anogenital distance
    • Eye opening
    • Incisor eruption
    • Pinna unfolding
    • Preputial separation
    • Testicular descent
    • Vaginal opening
  • Combined 28-day/reproduction screening
  • Developmental neurotoxicology
  • Extended One Generation Reproductive Toxicity Study (EOGRTS) 

Smithers-sperm piercing egg

Developmental and Reproductive Toxicology (DART) Scientific Instruments:

  • Sperm Motility and Density using Hamilton Thorne IVOS II
  • Automated Behavioral Assessment through Kinder
  • Avoidance Monitor II
  • Motor Monitor
  • Startle Monitor II