Endocrine Disruptor

About Endocrine Disruptor Testing Services:

Concern about chemically mediated modulation of normal endocrine (hormonal) function in wildlife and humans has become a focal point of concern in the scientific community and the public as a whole.

In 1996, the Food Quality Protection Act took action in the USA and directed the EPA to develop a screening program that would determine which chemicals may have hormone-altering effects. The Endocrine Disruptor Screening Program (EDSP) was established and has involved research and development aimed at establishment of testing guidelines for aquatic and terrestrial organisms.

More recently, the European Union charged EFSA and ECHA to develop guidance on how to identify endocrine disrupting pesticides and biocides. Any biocide assessed after June 2018 or pesticide after November 2018 must have endocrine activity evaluated.
 

Smithers-grandfather and grandson fishing

Smithers Viscient’s Endocrine Disruptor Testing Expertise:

Smithers Viscient provides in vivo testing to evaluate endocrine disruption for clients worldwide. As a leading provider during the EDSP Tier 1 programme, Smithers is the lab of choice for the evaluation of biocides and pesticides to meet the new EU guidance from ECHA and EFSA.

For androgen and estrogen endpoints, the FSDT (OECD 234), FSTRA (OECD 229), 21-Day (OECD 230), MEOGRT (OECD 240) are available. Thyroid activity can be assessed with the AMA (OECD 231) and LAGDA (OECD 241). All tests can be conducted to EU regulations under OECD and / or US EPA requirements (OCSPP/OPPTS).

The Harrogate and Wareham facilities have performed these studies either as standalone designs, or as combinations of the established OECD test guidelines to meet specific requirements. Smithers Viscient appreciates that each compound is unique and testing may need to be tailored to generate the endpoints relevant for risk assessment.

In addition to laboratory testing of potential endocrine disruptor chemicals, Smithers Viscient has also developed field deployable techniques to monitor exposure of avian species to environmental estrogens. Both laboratory and field deployable techniques have been developed to measure hormonal status in various measurable parameters from excreted hormones to mate selection and nesting behavior.
 

Endocrine Disruptor Testing Guidelines:


 

Resources:
Infographic - Fish Endocrine Testing Considerations - Fathead Minnow V's Medaka.

Webinar -  "Endocrine Disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009" - This webinar will discuss key aspects of the guidance document, including new key phrases like EATS mediated parameters and sensitive to but not diagnostic of EATS mediated parameters, new considerations like maximum tolerated concentrations in ecotoxicology studies, relevant OECD tests and potential strategies for assembling and collecting the necessary data for assessment. We will also walk through the assessment strategy flow chart using the new terminology and understanding where and how to use some of the proposed test methods.