Residue Chemistry

About Residue Chemistry Services:

Smithers Viscient provides GLP-compliant residue chemistry studies for registration and environmental monitoring needs.

Our analytical chemists have expertise in method development and method validation, and can design and implement fully customizable multi-residue testing programs for both active ingredients and metabolites. Smithers Viscient has developed HPLC and GC methods for a wide variety of matrices, including plant materials, soil, water, air, and processed food, animal feed and animal tissues. These methods are fully validated according to the latest EPA and SANCO guidelines. Our experienced chemists quantitatively measure the active ingredient (AI) and its metabolites – or the degradation products produced from the AI.

Smithers-gantry arm spraying crops

Smithers Viscient’s Residue Chemistry Expertise:

Smithers Viscient provides GLP-compliant residue chemistry studies for registration and environmental monitoring needs. Our expert team has experience in analyzing all major residue matrices. Smithers Viscient delivers timely, cost-effective sample generation and analysis. We can coordinate and conduct field trials in growing regions across North America and Europe. Samples are processed and analyzed at our laboratories.

 For over 45 years, Smithers Viscient has conducted studies to meet internationally-recognized testing guidelines. We test a wide variety of crop protection products, and our responsive team manages studies from initiation to submission to ensure on-time delivery. Our analytical chemists have expertise in method development and method validation, and can design easily customized multi-residue testing programs for both active ingredients and metabolites. 



  • Analytical method development and validation
  • Field dissipation
  • Field trials in collaboration with field contractors
  • Decline of residue (DEC), magnitude of residue at harvest (MOR) groundwater and surface water studies
  • Dislodgeable foliar residue studies
  • Worker exposure studies
  • Magnitude of residue
  • Maximum residue limits (MRL)/Import tolerance
  • Independent laboratory validations (ILV)
  • Feeding Studies
  • Fish and shellfish residue studies
  • Laboratory-scale fumigation studies
  • Food process control and monitoring
  • Human food safety and residue analysis
  • Storage stability/product shelf life
  • Analysis of water for aqueous studies (fish, daphnia, algae)
  • Verification of dosing /application in animal studies
  • Sample receipt, inventory, pre-processing, and frozen storage
  • Aged samples originating from 14C-metabolism, field or feeding studies (plant or animal) or dissipation (soil, sediment or water) studies
  • Modelling kinetic data—generated from metabolism studies and environmental fate evaluations 
  • Degradation pathways
  • Storage stability testing of residue samples


Residue Chemistry Guidelines:

All methods used are in full compliance with SANCO/825/00 rev.6 (2000) and OPPTS 860.1340.


OPPTS Guidelines supported include:

  • 860.1300 – Nature of the Residue–Plants, Livestock (August 1996)
  • 860.1340 – Residue Analytical Method (August 1996)
  • 860.1360 – Multi-residue Method (August 1996)
  • 860.1380 – Storage Stability Data (August 1996)
  • 860.1400 – Water, Fish, Irrigated Crops (August 1996)
  • 860.1480 – Meat/Milk/Poultry/Eggs (August 1996)
  • 860.1500 – Crop Field Trials (August 1996)
  • 860.1520 – Processed Food/Feed (August 1996)
  • 835.6100 – Terrestrial Field Dissipation (October 2008)
  • 875.2100 – Foliar Dislodgeable Residue Dissipation (February 1996)
  • 875.2200 – Soil Residue Dissipation (February 1996)


OECD Guidelines supported include:




Residue Chemistry Equipment and Instrumentation includes:

Smithers Viscient has a variety of instrumentation, including an LC/MS/MS with Qtrap used for metabolite ID. Other equipment includes 5 mass specs, 12 HPLCs, 6 GCs and 2 GCMS. Our diverse instrumentation allows us to analyse a wide variety of chemicals with a high and cost-effective throughput of samples.

  • HPLC with UV, DAD.14C, and ELSD Detectors,
  • LC/MS/MS (Sciex API 3000, 4000, 4000 Q trap, 5000, and 5600)
  • UPLC (Waters Acuity)
  • Gas Chromatography (GC) with EC, NPD, FID, MSD
  • Headspace injection System
  • Capillary Electrophoresis
  • Ion Chromatography
  • Ultraviolet-Visible Spectroscopy
  • Fluorescence Spectroscopy
  • Fourier Transform Infrared Spectroscopy
  • Raman Spectroscopy
  • One- and Two-Dimensional Electrophoresis
  • Accelerated Solvent Extraction
  • ASE Extractors (Dionex 200)


Storage Facilities:

  • Continuously monitored, environmentally controlled storage
  • Freezer rooms monitored to record specimen and air temperature set to maintain temperatures below -18°C
  • Cold room set to maintain 4°C   


Additional Resources for Residue Chemistry:

Geno Grinder Extraction
QUEchERS Methodologies


EXCLUSIVE WEBINAR - NOW AVAILABLE ON-DEMAND: 'Feeding Studies - Residues in Livestock', To register, click here.

Feeding Studies Infographic: Smithers has created a handy reference guide to illustrate the progression of a feeding study, this includes:
  • What to analyse
  • Understanding what to dose
  • Concentration levels
The guide explains the Smithers approach- from method development to final study report - including overall timeframe.
Download the Feeding Studies Infographic Guide.


Related Articles:

Residue Chemistry Analysis