Product Chemistry

About Product Chemistry Services:

Smithers Viscient performs product composition investigation, identification and quantification of the contents in a technical grade product subject to registration. Our capabilities include screening of ingredients to 0.1% and lower. Smithers Viscient has considerable experience in trace level analysis for the detection and identification of toxicologically significant impurities for preliminary 5-batch analysis, as well as experience in structure elucidation. 

 

Smithers Viscient’s Product Chemistry Expertise:

In addition to having extensive experience with a very broad range of test article chemistries, our Product Chemistry team has over a 100 years combined experience. 

 

Product Chemistry Capabilities:

  • Melting Point/Freezing – OECD 102
  • Boiling Point – OECD 103
  • Relative Density – OECD 109
  • Vapour Pressure – OECD 104
  • Surface Tension – OECD 115
  • Water Solubility (Shake Flask Method) – OECD 105
  • Water Solubility (Column Elution Method) – OECD 105
  • Partition Coefficient (HPLC) – OECD 117
  • Partition Coefficient (Shake Flask Method) – OECD 107
  • Partition Coefficient (Slow-stirring method) – OECD 123
  • Partition Coefficient (pH metric method) – OECD 112 (Draft)
  • Dissociation Constant – OECD 112
  • Flash point (Liquid only) – EC A9
  • Flammability (Solid on ignition) – EC A10
  • Flammability (Gases) – EC A11
  • Flammability (Contact with Water) – EC A12
  • Pyrophoric Properties of Solids and Liquids – EC A13
  • Explosive Properties (Liquid) – EC A14
  • Explosive Properties (Solid) – EC A14
  • Auto-ignition Temperature (Liquid) – EC A15
  • Relative Self-Ignition Temperature (Solid) – EC A16
  • Oxidising Properties (Solid) – EC A17
  • Oxidising Properties (Liquid) – EC A21
  • Viscosity – OECD 114
  • pH, acidity and alkalinity – OECD 122
  • Hydrolysis as a function of pH – OECD 111
  • UV/Visible Absorption – OECD 101
  • Color (Munsell System) – OPPTS 830.6302
  • Corrosion Density – OPPTS 830.6320
  • Certificate of Analysis
  • Explodability – OPPTS 830.6316; (for solids EC A.14 can be used)
  • Miscibility – CIPAC MT 23; OPPTS 830.6319
  • Odor
  • Oxidation/Reduction – OPPTS 6304
  • Particle Size (sieving)
  • Physical State – OPPTS 830.6303
  • Preliminary Analysis (5-batch analysis) – OPPTS 830:1700
  • Solvent Solubility
  •  Fat solubility – OECD 116
  • Storage Stability

 

Product Chemistry Guidelines:

  • OECD
  • CIPAC
  • OPPTS/OCSPP
  • EU Method

 

Product Chemistry Equipment and Instrumentation includes:

  • HPLC with UV, DAD.14C, and ELSD Detectors,
  • LC/MS/MS (Sciex API 3000, 4000, 4000 Q trap, 5000, and 5600)
  • UPLC (Waters Acuity)
  • Gas Chromatography (GC) with EC, NPD, FID, MSD
  • Headspace injection System
  • Capillary Electrophoresis
  • Ion Chromatography
  • Ultraviolet-Visible Spectroscopy
  • Fluorescence Spectroscopy
  • Fourier Transform Infrared Spectroscopy
  • Raman Spectroscopy
  • One- and Two-Dimensional Electrophoresis
  • Accelerated Solvent Extraction
  • ASE Extractors (Dionex 200)